On the contrary, DNA mismatch repair (MMR) pathway inhibition seems to have the same effect, by increasing the tolerance of the cancer cells to damage, leading to mutagenicity and chemoresistance [107]
Conclusion: Given the critical role of mitochondrial function in safeguarding renal functional integrity, the enhancement of mitochondrial energy metabolism and antioxidant status in kidney tissue is likely involved in renal protection
In industry, glutathione and reduced glutathione (GSH) are used as functional ingredients in pharmaceuticals, dietary supplements, cosmetics, and some food applications, where their antioxidant and reducing properties help stabilize formulations and support health-oriented product positioning
They reduce hydrogen peroxide and organic hydroperoxides to water or alcohols by oxidizing GSH to GSSG
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Noma K, Goto C, Jitsuiki D, Ueda K, Kimura M, Nishioka K, et al