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The nuclear factor E2 related factor 2 (Nrf2/NFE2L2) has been proved to play a key role in neurodegenerative disease treatment and ferroptosis regulation

This switch is accompanied by a shift in the position of the cleaved P i ion and of the Mg 2+ ion (pink), which stably bridges the P i and ADP (top)

In other studies, investigators found that exendin-4 significantly reduced levels of amyloid beta protein (a hallmark of Alzheimers disease) and its precursor molecule in mice models of the disorder