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Mice undergoing in vivo reprogramming were found to become depleted in B 12 and show signs of methionine starvation while supplementing reprogramming mice and cells with B 12 increased reprogramming efficiency, indicating a cell-intrinsic effect

Hydroxocobalamin injections are the UK first-line treatment, administered intramuscularly to ensure reliable B12 delivery independent of gut absorption

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Injectable B12 effectively corrects deficiency, with hydroxocobalamin being the preferred formulation in the UK due to its longer retention in the body