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The use of compounded drugs in patients using GLP-1s without medical supervision pose significant risk and can result in significant consequences, said Marina Basina, MD, a clinical professor in endocrinology, gerontology and metabolism

Combined with adequate protein intake (widely recommended at 1.2-1.6g per kg of body weight during GLP-1 protocols) and resistance training, the higher dose ranges may actually preserve lean mass better than lower doses, because the energy deficit is being met predominantly through fat oxidation rather than muscle catabolism

Do not attempt a 4mg dose at this concentration because 1.60mL exceeds what a standard 1mL insulin syringe can hold, and the injection volume itself becomes uncomfortable

There is also substantial impact on overall lifespan with an estimated 520 years of life lost for individuals with a BMI 45 [9]

Resources like the SeekPeptides peptide calculator can handle these calculations automatically if you prefer not to do the math yourself

however, Wegovy contains a much higher dose of semaglutide