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As GLP-1 analogs, GLP-1RAs effectively regulate blood glucose by inhibiting glucagon secretion, slowing gastric emptying, enhancing insulin sensitivity, and stimulating insulin secretion [51]

Yes, the GLP-1 released from our intestinal cells is rapidly degraded, leading to low systemic levels, but its effects appear to be mediated by vagus nerve stimulation

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Bull Exp Biol Med 146(5):624626