Increased intracellular Ca 2+ activates Ca 2+ -dependent K + channels (Gardos channels), promoting K + efflux and cell shrinkage, while also stimulating scramblases that drive PS externalization (Lang et al., 2003)
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A previous study also found that GLP1 may stimulate the secretion of insulin in cells and induce glucose catabolism via the mTOR-dependent HIF-1 activation pathway (Figure 2) [92]
D.FrydmanR
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[16] Reported rates from trials include: Nausea: ~44% Vomiting: ~25% Diarrhea: ~31% Constipation: ~23% Dyspepsia: ~10% These effects reflect slowed gastric motility and are usually mild, but can lead to clinical implications: Dehydration Electrolyte abnormalities ED presentations for poor oral intake