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Specific targeting of glioblastoma with an oncolytic virus expressing a cetuximab-CCL5 fusion protein via innate and adaptive immunity

In less deficient areas, repeat dose every 5 - 6 months or as necessary

It should also be avoided in patients with coexisting uncontrolled liver diseases (eg, autoimmune hepatitis), uncontrolled hypothyroidism or hyperthyroidism, symptomatic gallstone-related diseases, and ongoing alcohol consumption of 20 g or more per day for women or 30 g or more per day for men

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Profitability risk: Rising biosimilar manufacturing costs, driven by raw material inflation and cold chain cost increases, combined with accelerating ASP erosion in multi-entrant markets, have already forced several biosimilar manufacturers to exit specific product markets or delay launches

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