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In some embodiments, the otoprotectant is a compound of Formula (V): wherein: R 1 is C 6 -C 10 aryl or C 3 -C 9 heteroaryl, wherein C 6 -C 10 aryl and C 3 -C 9 heteroaryl are optionally substituted with one or more R 4

10.1089/neu.2018.5844 J

Rusciano D, Russo C

The IGF Binding Protein Problem To understand why IGF-1 LR3 matters, you need to understand IGFBPs

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J Immunother Cancer, 2023