In a maintenance trial, nausea affected 47% of participants during escalation but fell to 14% after the same 2.4 mg dose was held. Receptor exposure stayed constant
The FDA has approved several GLP-1 receptor agonists, including semaglutide (Ozempic, Wegovy), dulaglutide (Trulicity), and liraglutide (Victoza, Saxenda)
PLoS One 5 , e9449 (2010)
HDFA treatment targets the blockage in the transportation of folate into the brain through the folate receptor alpha caused by blocking or binding autoantibodies (Frye et al., Overall, this study provides some insight to the potential benefits of safe and well-tolerated therapies that target specific metabolism abnormalities associated with ASD
Linos E, Swetter SM, Cockburn MG, et al
While oral DFP has a risk of hematological toxicity (Ruivard and Lobbes, 2023), oral DFX can cause hepatic and renal toxicity and gastrointestinal bleeding with chronic use (Yusuf et al., 2023)