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Without peer-reviewed human data, assertions of efficacy or safety stand primarily on animal studies, case reports, and anecdote

A 1ml syringe is often sufficient for typical B12 doses

Caffeine (250 mg) is also commonly administered orally to investigate the effect of cirrhosis on the disposition of the liver and the elimination of drugs from it (Desmond et al., 1980)

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Sulforaphane- or glucoraphanin-rich broccoli sprout extracts provide one avenue towards this end