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Furthermore, autoantigens released by epithelial cells can also enable auto-Abs to form circulating ICs, which further stimulate production of cytokines [191]

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For instance, a considerable quantity of nanoparticles was phagocytosed by macrophages in vivo , surpassing the RES threshold and penetrating the immune barrier, thereby prolonging the circulation time of blood and facilitating accumulation in tumors (Ouyang et al., 2020)