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Sitagliptin is an inhibitor of DPPiv which degrades the active form of GLP1 (Drucker, 2021)

Researchers compared women who took the drug alongside hormone therapy with women who took just the GLP-1 and found that women who took both lost more weight than those just taking the weight loss drug alone

After 12 months, most participants regained one-third of their body weight Unfortunately, after successful stints on semaglutide 2.4 mg, participants regained most of their body weight within the first 12 months of withdrawal

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This multi-target profile allows researchers to explore coordinated receptor activity compared to single or dual receptor compounds under controlled laboratory conditions

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