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Gln, a nonessential amino acid abundant in the bloodstream, along with its metabolites lutamate and ketoglutarate (-KG), serves as a vital source of carbon and nitrogen, providing essential raw materials for the synthesis of nucleotides and amino acids ( Although some Gln metabolic inhibitors have entered clinical trials, the heterogeneity among tumors complicates their effectiveness

For instance, increased cysteine availability in plasma is related to an enhanced risk of breast cancer, particularly oestrogen receptor-positive (ER + ) and/or progesterone receptor-positive (PR + ) cancer and in combination with low folate availability in plasma