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These have accorded GSTs properties consistent with promiscuous substrate specificities geared to act on functional groups rather than specific compounds (Tables 1 and 2)

Graphical Abstract Similar content being viewed by others Abbreviations ALD: Alcoholic liver disease ALT: Alanine aminotransferase AST: Aspartate aminotransferase CAT: Catalase GGT: Gamma-glutamyltransferase Glu: Fasting blood glucose GSH-Px: Glutathione peroxidase HDL: High-density lipoprotein HFDs: High-fat diets HOMA-IR: Homeostasis model assessment of insulin resistance IL-1: Interleukin-1 beta IL-6: Interleukin-6 iNOS: Inducible nitric oxide synthase LDL: Low-density lipoprotein MASLD: Metabolic dysfunction-associated steatotic liver disease NF-B: Nuclear factor kappa B SM: Silymarin SM-PNPs: Silymarin-loaded phytosomal nanoparticles SOD: Superoxide dismutase SPC: Soy phosphatidylcholine TC: Total cholesterol TG: Triglycerides TNF-: Tumor necrosis factor-alpha Acknowledgements Authors are thankful to the research assistant staff of Mansoura experimental research center (MERC) for their help and support through the current study

Vitamin C is used in Glutathione to prevent depletion of antioxidant properties

IGFs are involved in multiple stages of cancer development

Nausea, vomiting, diarrhea, constipation, and abdominal pain were mainly transient and mild to moderate

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