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Travel adds legal, documentation, temperature, and chain-of-custody issues that are separate from shelf life

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Unlike the spray pattern (which does not require PBE analysis), plume geometry equivalence is assessed with the criterion that the test products plume angle and width fall within 90111% of the reference product values

However, the effect of NSAIDs on lower esophageal sphincter and pyloric sphicter pressure is far less studied, and is inconsistent and not fully described (16-23)

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