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Fewer people needed rescue therapy for hyperglycaemia in the orforglipron groups: 3% and 2% on 12 mg and 36 mg, respectively, compared to 12% and 6% in the 7 mg and 14 mg oral semaglutide groups

PCOS is often marked by insulin resistance and "estrogen dominance" - excess circulating estrogen relative to progesterone

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We monitor not just weight loss but improvements in metabolic markers, energy levels, and quality of life measures throughout treatment

The risk of a missed interaction or a subtle disease change going unnoticed increases with medication complexity