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Biochim Biophys Acta (2007) 1768(4):91322

Global expression analysis of endometrial cancer cells in response to progesterone identifies new therapeutic targets

Packer, L., Witt, E

Journal of cardiovascular pharmacology

Melasma develops due to several factors: Hormonal changes (pregnancy, oral contraceptives) Genetic predisposition Skin inflammation or irritation Certain medications Cosmetic products Heat and UV exposure Excessive sun exposure Sun exposure remains the strongest trigger , making sunscreen essential in treatment