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Since natural glutathione production also decreases, there's little defense against the increase in oxidative stress

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These effects are seen even outside of diabetes control.[ref] Related article: APOE genotype and Alzheimers risk Cardiovascular disease benefits: A number of studies have shown that GLP-1 RAs provide benefits for reducing cardiovascular disease

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Arthur GL, Schwartz MZ, Kuenzler KA, Birbe R (2004) Glucagonlike peptide-2 analogue: a possible new approach in the management of inflammatory bowel disease