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This schedule, documented across SURPASS clinical trials, starts at the lowest therapeutic dose and increases by 2.5 mg every four weeks

In these metabolic trials, psychiatric outcomes were not pre-specified primary endpoints

No evidence of cumulative worsening emerged in the Retatrutide trials

Most common (especially in first 4-8 weeks): Nausea Early fullness/satiety Constipation Mild reflux or burping Less common but important: Severe nausea preventing adequate eating or drinking Gallbladder issues (rapid weight loss increases gallstone risk) Pancreatitis (rare, more common with high triglycerides or gallstone history) Dehydration The side effect no one mentions: Undereating

doi: 10.1016/S0140-6736(18)32260-8 112 FrasJPDaviesMJRosenstockJPrez ManghiFCFernndez LandLBergmanBKet al

Participants achieved weight reductions of up to 15.1% at 32 weeks approximately 40% greater than cagrilintide monotherapy results [6]