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As we age, our liver metabolism changes

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[56] It achieves glycemic control primarily through a glucose-dependent mechanism: by binding to GLP-1 receptors on beta cells, it elevates intracellular levels of cyclic AMP (cAMP) and activates protein kinase A (PKA) and related signaling pathways

This magnitude of loss was previously achievable only through surgery

Tirzepatide is a once-weekly injectable medication approved by the FDA for the treatment of type 2 diabetes (marketed as Mounjaro) and chronic weight management in adults with obesity (BMI 30 kg/m) or overweight (BMI 27 kg/m) with at least one weight-related comorbidity (marketed as Zepbound)