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As for nonfatal stroke, GLP-1 RA are the only drug class that significantly reduces nonfatal stroke, as compared with placebo, without any difference among the three classes of drugs

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However, the authors concluded that DMH LepR neurons are not essential for satiation or satiety, as the study found no significant increase in food intake or body weight following inhibition or disruption of these neurons [54]

A 2022 analysis in The New England Journal of Medicine reported that the 15 mg dose produced 20.9% mean body-weight reduction at 72 weeks compared with 3.1% for placebo in the SURMOUNT-1 trial (N=2,539) [1]

doi: 10.1007/s40263-013-0119-1 151 VogelzangsNBeekmanATVan Reedt DortlandAKSchoeversRAGiltayEJDe JongePet al

Keep a simple journal during this phase