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Clinical data suggests an average of two to four pounds lost in the first four weeks at starting doses, with considerable variation based on individual baseline metabolism and activity levels

But you do need to have a conversation with your prescribing provider

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[27] Until Phase 3 data are available and regulatory review is complete, the full clinical profile of retatrutide remains under investigation, and all findings should be interpreted with appropriate caution

Most clinical trials utilize a stepwise approach, where people start at a lower dose and ramp up