Any unapproved use of an FDA-approved drug is considered off-label. For example, a patient taking Ozempic for weight loss instead of type 2 diabetes management is using the drug for off-label reasons
Infliximab: a review of its use in the management of rheumatoid arthritis
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At the same time, increased levels of inflammatory molecules, such as LPS from harmful bacteria, can lead to systemic-wide inflammation (Obrenovich et al., 2020)