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Kitakata H, Endo J, Matsushima H, Yamamoto S, Ikura H, Hirai A, et al

doi: 10.1371/journal.ppat.1007390 209 OnofrioL.CaragliaM.FacchiniG.MargheritaV.De PlacidoS.BuonerbaC

We may produce a ton of it, but we also do a lot of things that cancel it out: eating poorly, spending time in highly polluted areas, or taking too many medications

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The association of ROS with neuronal degeneration in PD is further substantiated by modeling the Parkinsonian phenotypes in animals through 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), rotenone, 1,1-dimethyl-4,4-bipyridinium dichloride (paraquat), or 6-hydroxydopamine (6-OHDA), those are known of elevate the oxygen free-radicals in the cell 18