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Naot D, et al
Rahman et al., 2007)
The subsequent pathophysiologic mechanisms can be summarized as acute tubular apoptosis, oxidative stress, inflammation, microcirculatory dysfunction, vascular barrier function disorder, local hypoxia, and tissue edema (84)
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In the first reaction, ethanol loses a proton (H + ), and a hydride ion (H ) is transferred from the ethanol to NAD + to reduce it to NADH, resulting in an enhanced NADH/NAD + ratio
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