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The peptide undergoes rapid first-pass metabolism when absorbed, which is why bioavailability varies significantly by administration route
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This breadth of effect is consistent with a mechanism operating at the level of chromatin architecture rather than through specific receptor binding
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Chieppa M, Rescigno M, Huang AYC, Germain RN (2006) Dynamic imaging of dendritic cell extension into the small bowel lumen in response to epithelial cell TLR engagement
It also is involved with gene regulation, cell signaling, and promoting the metabolism of fatty acids, glucose, and amino acids
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