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In AD, improved learning and memory abilities caused by intake of GLP-1RAs correlated with a decrease in chronic inflammation, -amyloid plaques in the brain, hyperphosphorylation of tau protein, protection of mitochondria, and optimization of energy metabolism
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Most treatment discontinuations were due to gastrointestinal AE and occurred during the rapid escalation phase this may be mitigated with more gradual dose escalation at phase 3 trials
GLP-1 agonist signaling
Mechanisms of podocyte injury and implications for diabetic nephropathy