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They include activating mutations of HRAS and rearrangements of receptor tyrosine kinases ( ROS1 , ALK , MET , NTRK1 , NTRK3 , RET , MERTK ) or serine/threonine kinases involved in the MAPK pathway ( BRAF , RAF1 , MAP3K8 ) that lead to constitutive kinase activity [5, 24,25,26,27,28,29,30]

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"Usually, it's self-limited, but in rare cases, it can get serious," Khan says

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