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Glucagon-like peptide-1 and HPG axis GLP-1 is an intestinal hormone secreted postprandially from the intestinal L cells in the distal ileum and proximal colon in response to nutrients intake

There was a substantial increase in intracellular uptake of semaglutide by gastric epithelial cells with SNAC exposure compared with control, which was not apparent with EDTA, a modulator of tight junction function

13 The latest meta-analysis shows that AN adult patients have an average reduction of 0.16 kg in whole-body bone mineral content, 14 and there is no gender difference in the reduction of BMD in adolescent patients, 15 In terms of bone microstructure, abnormalities are observed in the distal radius and distal tibia of AN patients, manifested as reduced volumetric bone mineral density (vBMD), decreased cortical bone area and thickness, increased porosity, decreased trabecular bone density and increased separation degree, but the results of studies on trabecular bone number changes are inconsistent

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doi: 10.2337/dc10-0666 237 GandiniSPuntoniMHeckman-StoddardBMDunnBKFordLDeCensiAet al

Alteration of peptidergic gut-brain signaling under conditions of obesity