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3.6 Epithelialmesenchymal transition EMT is a complex biological process in which renal tubular epithelial cells lose their characteristic features and acquire mesenchymal-like properties ( In DKD, in response to severe or persistent inflammation, TECs undergo EMT through various signaling pathways, such as TGF-, Wnt/-catenin, PI3K/Akt, JAK/STAT, and Notch pathways ( Nevertheless, the precise detection of EMT in renal tissues remains challenging, and the development of effective anti-EMT therapies has been impeded for a long time

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Histone modifications Histone modifications, through the dynamic remodeling of chromatin structure, exert multidimensional regulatory effects across the various stages of acute injury, metabolic reprogramming, and chronic ventricular remodeling in MI, serving as critical nodes determining cardiomyocyte fate and tissue repair 93,94,95

Its phytochemical composition is largely responsible for its efficacy in treating diabetes, PD, and ED

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