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With limited budgets available, it is important to prioritize the funding of research that has the greatest potential to efficiently improve health outcomes

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Naltrexone/bupropion ER (maximum oral dosage of 16 mg/180 mg, twice daily) produces an anticipated average 3% total body weight reduction and has an NNT of 7 (95% CI, 4 to 18) for producing weight loss of 10% or more and an NNT of 12 (95% CI, 6 to 30) for producing weight loss of 15% or more

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