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The PIONEER 6 study included 3183 T2DM patients who had ASCVD or who were at high risk, of whom 1591 were treated with oral semaglutide and 1592 were treated with placebo for a median time of 15.9 months [40]
If taking oral semaglutide, take it at a completely different time (some clinicians recommend evening dosing for one or the other)
Because the science is still evolving, doctors and researchers dont fully understand why people respond so differently to these medications
The Authors reported that treatment with incretins significantly suppressed the FSH-induced synthesis of progesterone through the inhibition of the expression of progestogenic factors and enzymes, whereas there was no significant effect on oestrogen synthesis by rat granulosa cells, thus suggesting the possible role of GLP-1 RA in the treatment of dysregulated steroidogenesis in PCOS [43]
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Clinical trials show an average weight loss of around 21%
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