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These data provide an explanation for CNS activation even though monoclonal antibodies have minimal brain penetrance, reaching concentrations of around 0.10.4% of the monoclonal antibody concentrations in the plasma 50,51

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doi:10.1155/2012/434971, PMID: 22745639 Velu CS, Niture SK, Doneanu CE, Pattabiraman N, Srivenugopal KS (2007) Human p53 is inhibited by glutathionylation of cysteines present in the proximal DNA-binding domain during oxidative stress

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