semaglutide vs tirzepatide mechanism difference vs Retatrutide: Canada 2026 Semaglutide vs Tirzepatide Differences

Physically, the typical side effects: acid reflux and constipation, mainly, both of which are easily managed

Prescription GLP-1 receptor agonists have undergone rigorous, large-scale clinical trials showing significant efficacy in lowering blood glucose levels, promoting substantial weight loss, and even offering cardiovascular benefits in some cases

Nat Rev Neurol 15:691703

And because we have these longer-acting medicines than what our own GLP-1 can do, it can last longer

The focus here should be on maintaining adequate protein intake (80 to 100 grams daily) and staying physically active to preserve muscle mass during rapid weight loss

GLP-1 drugs are also showing promise for many other conditions, including fatty liver disease