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PMID: 19227576

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[DOI] [PMC free article] [PubMed] [Google Scholar] 93.Howrigan DP, Rose SA, Samocha KE, Fromer M, Cerrato F, Chen WJ, et al

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However, DAMPs alone are insufficient to explain the initiation of PEM, especially in post-infectious syndromes such as PCC, where PAMPs may play a crucial role ( 3.1 Mitochondria-driven inflammatory signaling Mitochondrial dysfunction may lead to the overproduction of ROS and the release of mtDNA into the cytoplasm (108110), which subsequently may activate the NLRP3 inflammasome (111, 112)