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In cancer patients, a detrimental effect of vitamin D supplementation may be associated with defective VDR signaling, according to data from preclinical studies: VDR deficiency could lead to the loss of vitamin D's beneficial effects and possibly the emergence of harmful effects, such as the upregulation of tumor angiogenesis and suppression of anti-tumor immunity (7377)

however, these benefits were limited only to obese patients (99)