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A 2001 editorial in the European Journal of Anesthesiology called DSIP "incredibly safe" because no published research had ever recorded a fatal dose in any animal model

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The medications carry FDA boxed warnings related to thyroid C-cell tumors in rodent studies these have not been definitively shown in humans but are part of the warning label and contraindicate use in patients with a personal or family history of medullary thyroid cancer or MEN-2

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Detailed ePA Implementation for GLP-1 Drugs 4.1