What GLP-1s do in your body: Stimulate insulin release from pancreatic beta cells Slow gastric emptying, which reduces appetite Get metabolized primarily by the liver Are cleared partially through kidney function Have unknown long-term effects on thyroid C-cells Nearly half of patients stop GLP-1 therapy within the first year
Rotating Injection Sites to Prevent Lipohypertrophy Lipohypertrophya thickening or lumping of fat tissueoccurs when you inject the same spot repeatedly and can reduce medication absorption by up to 25 percent over time
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Insert the needle at a 90-degree angle perpendicular to skin, aim for subcutaneous tissue rather than muscle, and alternate between thighs, abdomen, and upper arms each week
Cost : Semaglutide can be expensive, and insurance coverage may vary
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