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The primary endpoint was AUC 0 for plasma cagrilintide from baseline (day 1) to day 39 (end of study)

MC4R activity is also linked to sexual function, which explains why related peptides like PT-141 focus more on this pathway

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The liver from Gclc L-KO mice showed rapid depletion of Gclc mRNA and progressive loss of GCLC protein and GSH levels (Fig