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By binding to p53, it induces nuclear exclusion, allowing p53 to translocate to the cytoplasm and mitochondria, subsequently activating the p53/BCL-2/Caspase-3 signaling pathway to execute selective apoptosis in senescent populations (Frontiers, 2025

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Materials and methods The study was registered at ClinicalTrials.gov (id: NCT01312571), and approval was obtained from the regional ethics committee at Ume University, Sweden (dnr: 2015-310-31 M)

Curr Biol 10(11):640648 Hedayati N, Safari MH, Milasi YE, Kahkesh S, Farahani N, Khoshnazar SM et al (2025) Modulation of the PI3K/Akt signaling pathway by resveratrol in cancer: molecular mechanisms and therapeutic opportunity

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