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After 52 weeks, 26% and 30% of participants who received 80 mg and 100 mg of resmetirom, respectively, achieved MASH resolution with no fibrosis worsening compared to 10% on placebo ( p 10 million patient-years of exposure in diabetes and obesity [4, 35]
Long-acting glucagon-like peptide 1 receptor agonists: a review of their efficacy and tolerability
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doi: 10.1007/s10143-020-01403-2 5 StuppRMasonWPvan den BentMJWellerMFisherBTaphoornMJet al
FIGURE 2 3.6 Oxidative stress indices Adenine and STZ induced a significant increase in 8-OHdG, 8-isoprostane, and AGEs (Figure 3), an effect that was significantly attenuated by all the treatment combinations, but it was more pronounced with the GAmelatoninbetaine combination