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By week 3 of Wegovy (semaglutide) treatment, most patients are still in the initial dose titration phase, receiving the starting dose of 0.25 mg once weekly

However, some early findings suggest a complex relationship

In addition, compulsivity trait (OCI) was also related to changes in SMA Glu levels, both in healthy volunteers and participants with OCD, consistent with the notion of a transdiagnostic dimension characterising compulsive behaviour related to connectivity of frontal regions 2

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J Med Chem 64(7):34933507

& Bouilly, J