[DOI] [PMC free article] [PubMed] [Google Scholar] 72.Andersen A, Knop FK, Vilsbll T
Increased mucin secretion, particularly MUC5AC, is associated with asthma, and the mucus plugs generated by the asthmatic airway are hypothesized to be generated by eosinophil peroxidase crosslinking of mucus thiol groups to stiffen the mucus gels and prevent clearance (Dunican et al., 2018a)
Soberanes S, Misharin AV, Jairaman A, Morales-Nebreda L, McQuattie-Pimentel AC, Cho T, Hamanaka RB, Meliton AY, Reyfman PA, Walter JM, Chen CI, Chi M, Chiu S, Gonzalez-Gonzalez FJ, Antalek M, Abdala-Valencia H, Chiarella SE, Sun KA, Woods PS, Ghio AJ, Jain M, Perlman H, Ridge KM, Morimoto RI, Sznajder JI, Balch WE, Bhorade SM, Bharat A, Prakriya M, Chandel NS, Mutlu GM, Scott Budinger GR
Based on how it went with Zepbound and Wegovy, expect limited insurance coverage at first, especially for weight loss (diabetes coverage tends to be better)
It is FDA-approved under the brand name Vyleesi for hypoactive sexual desire disorder in women
It helps the liver eliminate fat deposits and produces S-adenosyl methionine (SAM), which governs lipid homeostasis and gene expression
