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Description

Lee and Schedl, 2010)

5-Amino-1MQ Animal Studies Studies using 5-Amino-1MQ specifically have demonstrated its potency and selectivity as an NNMT inhibitor, with IC50 values in the low micromolar range and good selectivity over other methyltransferases

Adding alcohol to this picture increases nausea risk significantly, since alcohol irritates the stomach lining and can trigger or worsen GLP-1-related gastrointestinal effects

The answer lies in its mechanism