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Chronic heavy drinking induces the microsomal ethanol-oxidizing system (MEOS) and CYP2E1 enzyme upregulation, increasing ethanol clearance speed while simultaneously generating reactive oxygen species that accelerate hepatocellular damage

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It would be important to seek evidence for the most effective route for the treatment of these patients Aims: To assess the response to oral versus intravenous vitamin B12 supplementation in anemia with vitamin B12 deficiency by the change in serum vitamin B12 level

Hardt K, Vandebosch A, Sadoff J, Le Gars M, Truyers C, Lowson D, et al

The absence of early response does not indicate treatment failure

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