Read clinical review Evidence-based guide to Wegovy (semaglutide 2.4 mg) dosing considerations for South Asian patients, including BMI thresholds, pharmacogenomic factors, and titration guidance
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[17] [18] Resistance training is particularly valuable for maintaining lean mass during pharmacological weight loss, as supported by body composition analyses from trials of GLP-1-based agents such as semaglutide and tirzepatide (STEP and SURMOUNT programme substudies)
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In retatrutide, the GLP-1 and GIP components offset this effect, keeping blood sugar stable while still capturing glucagon's fat-burning benefits (Jastreboff et al., NEJM 2023)