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Today 3 BaroneE.Di DomenicoF.PerluigiM.ButterfieldD

The C20 fatty diacid moiety enabling albumin binding extends the pharmacokinetic half-life to approximately 6-7 days, making once-weekly research dosing protocols practical

2023 May 21:657:69-79

Inborn errors Congenital defects involve enzyme deficiencies in the carnitine transport or metabolic pathways, such as CPT II deficiency, which affects the function of the carnitine transporter CPT II and leads to impaired fatty acid -oxidation, and CACT deficiency, which affects the function of the carnitine transporter CACT and results in carnitine shuttle dysfunction

Li, S., Brown, M