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Masuda, Y., Murai, S., Saito, H., et al

S tudy on the Critical Raw Materials for the EU 2023 (European Commission, 2023)

Methods Mol Biol 1263:243250

High NNMT expression is closely associated with glucose dysregulation: excessive NNMT activation disrupts nicotinamide metabolism, lowers NAD+ levels, impairs insulin signaling, reduces cellular glucose uptake and utilization, and promotes hyperglycemia and insulin resistance