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Identified CoUs include biomarkers of risk (e.g., APOE4 ), diagnosis (e.g., amyloid PET, CSF AD biomarkers), monitoring (e.g., blood-based biomarkers of p-tau and NfL), pharmacodynamic response (e.g., amyloid PET, tau PET), prognosis (p-tau, Up53), treatment response prediction (none known for predicting benefit

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