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In this context, PI3K and AMPK are considered critical molecular pathways in cells, regulating various functions, including metabolism and growth

The higher Rg values of the mGLP1-DARPin-1 and mGLP1-DARPin-2 fusion proteins than the nGLP1-DARPin indicate loose packing of the protein structure in the mutant systems, which means more flexible conformation

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Collectively, these results suggest that UA not only enhances oxygen delivery through improved cardiovascular function but also augments oxygen utilization at the muscular level both of which are critical determinants of increased VO max